PERAN VITAMIN D PADA URTIKARIA

THE ROLE OF VITAMIN D IN URTICARIA

Abstract

Urticaria (hives) is a skin reaction in the form of a rash, patches or bumps that appear
red and itchy. Urticaria is divided into two based on the duration of occurrence,
which is acute urticarial (AU) with a duration of <6 weeks and chronic urticaria (CU)
with a duration of more than 6 weeks. Acute urticaria is often associated with
infection or food or drug intake. Chronic urticaria can occur spontaneously, known
as chronic spontaneous urticaria (CSU), when no specific trigger is found. Chronic
urticaria can also be associated with systemic disorders or can be induced by obvious
stimuli, called chronic induced urticaria (CIndU).Vitamin D is a potential
immunomodulator as an alternative therapy for urticaria. The role of vitamin D by
modulating the immune system through its active metabolite 1,25(OH)2D, which is
indicated by the presence of vitamin D receptors on T cells, B cells, macrophages,
monocytes and dendritic cells. Vitamin D supplementation in patients with CU who
were deficient in vitamin D significantly reduced the severity of the disease. In
patients with vitamin D deficiency, the dose of administration is 7000-10,000 IU/day
(175- 250 mcg/day) or 50,000 IU/week (1250 mcg/week), with a duration of 1-3 months
and monitoring of serum vitamin D levels at least 8-12 weeks after the first dose is
given. The use of high doses of vitamin D (28000 IU/week) as adjunctive therapy has
been shown to reduce the severity of CU symptoms and the dose of allergy
medication.